At home I use a tower PC, have done for about 25 years. I rarely switch it off and then only for an immediate restart or for de-fluffing, so no more than an hour or so. Even when we are away in the van for a few weeks the PC is left on at home. We were going away recently for a few days and I arranged for an electrician to fit a new Consumer Unit in the house along with inspection and testing of all circuits. Before leaving I shut down the PC. It died. Diagnosis was 'Thermal Shock', it was so used to being on and running that when switched off and allowed to cool right down it packed up. Required a new motherboard and processor, fortunately not a huge cost. Memory, hard drive and other peripherals were fine. Having said that it was probably six or seven years old, and running on Windows 8. I now have a clean machine running on Windows 10. But, lesson learnt, I shall now be shutting down each night and re-booting in the morning.