Does it go in to limp home mode? Our Frankia based on a Sprinter 416CDI had the same problem. Assuming that it's not due to an air leak, we needed a new turbo, even with only 44,000 miles. The variable vanes were sticking, apparantly due to low mileage. My E220CDI went on to 342,000 miles on the original turbo; the car regularly travelled long journeys.
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